GABAA receptor signalling mechanisms revealed by structural pharmacology
نویسندگان
چکیده
منابع مشابه
GABAA receptor pharmacology.
gamma-Aminobutyric acid (GABA)A receptors for the inhibitory neurotransmitter GABA are likely to be found on most, if not all, neurons in the brain and spinal cord. They appear to be the most complicated of the superfamily of ligand-gated ion channels in terms of the large number of receptor subtypes and also the variety of ligands that interact with specific sites on the receptors. There appea...
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LYl7l555. SinLe forskolin activates adenylyl cyclase, effects of Dr receptors on Na'/X+-ATPase would then be mediated via protein phosphorylation and CAMP-dependent protein kinase. There are reports that Na+/K+-ATPase may be regulated by phosphoryl-ation, and CAMP has been reported to inhibit the enzyme via a cAMP-&pendent protein kinase7, consistent with the scheme outlined above. However, it ...
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ژورنال
عنوان ژورنال: Nature
سال: 2019
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-018-0832-5